In this report, we aim at presenting a viable strategy for the study of Epithelial-Mesenchymal Transition (EMT) and its opposite Mesenchymal-Epithelial Transition (MET) by means of a Systems Biology approach combined with a suitable Mathematical Modeling analysis. Precisely, it is shown how the presence of a metastable state, that is identified at a mesoscopic level of description, is crucial for making possible the appearance of a phase transition mechanism in the framework of fast-slow dynamics for Ordinary Differential Equations (ODEs).
Systems biology approach and mathematical modeling for analyzing phasespace switch during epithelial-mesenchymal transition / Simeoni, Corinne; Dinicola, S.; Cucina, A.; Mascia, C.; Bizzarri, M.. - STAMPA. - 1702(2018), pp. 95-123. [10.1007/978-1-4939-7456-6_7].
Systems biology approach and mathematical modeling for analyzing phasespace switch during epithelial-mesenchymal transition
SIMEONI, CORINNE;DINICOLA S.;CUCINA A.;MASCIA C.;BIZZARRI M.
2018
Abstract
In this report, we aim at presenting a viable strategy for the study of Epithelial-Mesenchymal Transition (EMT) and its opposite Mesenchymal-Epithelial Transition (MET) by means of a Systems Biology approach combined with a suitable Mathematical Modeling analysis. Precisely, it is shown how the presence of a metastable state, that is identified at a mesoscopic level of description, is crucial for making possible the appearance of a phase transition mechanism in the framework of fast-slow dynamics for Ordinary Differential Equations (ODEs).| File | Dimensione | Formato | |
|---|---|---|---|
|
Simeoni_Systems-biology-approach_2018.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
2.21 MB
Formato
Adobe PDF
|
2.21 MB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
